Fragile X is a genetic condition that causes "intellectual disability, behavioral and learning challenges and is also the most common known single gene cause of autism spectrum disorder," the Connect-FX site notes. Some believe the gel in question, ZYNOO2, may be able to improve the behavioral symptoms of Fragile X patients.
Buchanan says that individuals with Fragile X have difficulty regulating emotions and with social interactions. They are often socially isolated and withdrawn.
Scientists believe that the endocannabinoid system -- a part of the nervous system that helps regulate emotions, memory, appetite, and pain -- isn't operating properly in individuals with Fragile X. "Our body actually produces endocannabinoids," Buchanan says. "We theorize this biochemical pathway is somehow disrupted in people with neurodevelopmental disorders or difficulties."
Unlike tetrahydrocannabinol, the psychoactive chemical found in marijuana, the CBD gel used in the Connect-FX trial is non-euphoric and non-addictive. "We know it’s not going to cause a high and we can give an exact dose," Buchanan notes.
The sudden popularity of CBD oil to treat a number of conditions -- from sleep disorders to anxiety to whatever a snake oil salesman can dream up -- is one of the reasons scientists are studying the chemical with increased enthusiasm.The CBD oil you can buy online or in stores is not regulated by the U.S. Food and Drug Administration, and there are little to no guidelines for its use.
"That’s why this research is so important, so we can determine how to use it safety and what it is most effective for," Buchanan says. "I have quite a few families come in and they have seen benefits in CBD oil that they have purchased, but we don’t know the safety [of those products]."
The Greenwood Genetic Center study is currently enrolling patients across the state into the summer, with the results expected to be released by the fall. To apply for the trial, visit www.connectfxtrial.com.
Greenville Humane Society Mutt Strut is this weekend: Greenville Humane Society is hosting the 8th annual Mutt Strut Presented by Papa John’s, the largest dog-friendly race in the Southeast, on Saturday, April 27 at 8:30 a.m.
The 2019 Mutt Strut begins at 550 South Main St. in front of Halls Chophouse and leads runners and walkers on a two-mile course passing the Reedy River and Fluor Field. A Mutt Market Festival and After-Party will be hosted on South Main Street between the Army Navy Store and Mary's Cottage after the walk and run with family-friendly entertainment, including live music, sponsor tents offering giveaways, and free pizza.
“We look forward to one of the best Mutt Struts yet with an exciting new course through the heart of downtown,” said Chief Executive Officer Kim Pitman. “Greenville is a very dog-friendly city, and this is an invitation for our four-legged friends to strut down Main Street, a rare and unique experience. Our team is thrilled to have strong interest and support from the community as this is our top event that supports the animals at the Greenville Humane Society.”
Mutt Strut is the signature fundraiser for the Greenville Humane Society and provides support for the daily medical, food, and other needs of the animals cared for by the nonprofit organization. Participants are encouraged to raise funds as part of the race to help Greenville Humane Society reach its total fundraising goal of $50,000.
Registration is available at GHSMuttStrut.com, and those interested in participating are encouraged to sign up soon as spots are limited. The race fee is $35 per person, with discounted fees available for children. Group teams are encouraged, and people do not need to bring a dog to participate. --Kathleen Maris
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